Details

Name Glycine oxidase Synonyms

  • 1.4.3.19
  • GO
  • goxB
  • yjbR

Gene Name thiO Organism Bacillus subtilis (strain 168) Amino acid sequence 

>lcl|BSEQ0016486|Glycine oxidaseMKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTSAAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSEEDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKAAKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNAFLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLESVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILLAPATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI

Number of residues 369 Molecular Weight 40936.53 Theoretical pI 6.,32 GO Classification

Functions
flavin adenine dinucleotide binding / glycine oxidase activity
Processes
response to herbicide / thiamine biosynthetic process / thiamine diphosphate biosynthetic process
Components
cytoplasm

General Function Glycine oxidase activity Specific Function Catalyzes the FAD-dependent oxidative deamination of various amines and D-amino acids to yield the corresponding alpha-keto acids, ammonia/amine, and hydrogen peroxide. Oxidizes sarcosine (N-methylglycine), N-ethylglycine and glycine., Pode também oxidar o herbicida glifosato (n-fosfonometilglicina). Apresenta actividades mais baixas em D-alanina, D-valina, D-prolina e D-metionina. Não actua em L-aminoácidos e outros D-aminoácidos. É essencial para a biossíntese da tiamina, uma vez que a oxidação da glicina catalisada pelo tio gera o intermediário da glicina imina (dehidroglicina) necessário para a biossíntese do anel tiazole do pirofosfato de tiamina.,>

Resource Link UniProtKB ID O31616 UniProtKB Entry Name GLOX_BACSU GenBank Protein ID 2633520 GenBank Gene ID Z99110

General References

Drug Relations

Drug Relations

DrugBank ID Name Drug group Pharmacological action?, Actions Details
DB02713 Acetylamino-Acetic Acid experimental unknown Details
DB03147 Flavin adenine dinucleotide approved unknown Details