Details

Name Glycine oxidase Synonyms

  • 1.4.3.19
  • GO
  • goxB
  • yjbR

Gene Name thiO Organism Bacillus subtilis (strain 168) Amino acid sequence 

>lcl|BSEQ0016486|Glycine oxidaseMKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTSAAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSEEDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKAAKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNAFLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLESVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILLAPATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI

Number of residues 369 Molecular Weight 40936.53 Theoretical pI 6.,32 GO Classification

Functions
flavin adenine dinucleotide binding / glycine oxidase activity
Processes
response to herbicide / thiamine biosynthetic process / thiamine diphosphate biosynthetic process
Components
cytoplasm

General Function Glycine oxidase activity Specific Function Catalyzes the FAD-dependent oxidative deamination of various amines and D-amino acids to yield the corresponding alpha-keto acids, ammonia/amine, and hydrogen peroxide. Oxidizes sarcosine (N-methylglycine), N-ethylglycine and glycine., Może również utleniać herbicyd glifosat (N-fosfonometyloglicyna). Wykazuje mniejszą aktywność na D-alaninę, d-walinę, d-prolinę I d-metioninę. Nie działa na L-aminokwasy i inne d-aminokwasy. Jest niezbędny do biosyntezy tiaminy, ponieważ utlenianie glicyny katalizowanej przez tio generuje pośredni iminę glicyny (dehydroglicynę) wymaganą do biosyntezy pierścienia tiazolowego pirofosforanu tiaminy.,>

Resource Link UniProtKB ID O31616 UniProtKB Entry Name GLOX_BACSU GenBank Protein ID 2633520 GenBank Gene ID Z99110

General References

Drug Relations

Drug Relations

DrugBank ID Name Drug group Pharmacological action?, Actions Details
DB02713 Acetylamino-Acetic Acid experimental unknown Details
DB03147 Flavin adenine dinucleotide approved unknown Details