Details

Name Glycine oxidase Synonyms

  • 1.4.3.19
  • GO
  • goxB
  • yjbR

Gene Name thiO Organism Bacillus subtilis (strain 168) Amino acid sequence 

>lcl|BSEQ0016486|Glycine oxidaseMKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTSAAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSEEDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKAAKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNAFLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLESVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILLAPATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI

Number of residues 369 Molecular Weight 40936.53 Theoretical pI 6.,32 GO Classification

Functions
flavin adenine dinucleotide binding / glycine oxidase activity
Processes
response to herbicide / thiamine biosynthetic process / thiamine diphosphate biosynthetic process
Components
cytoplasm

General Function Glycine oxidase activity Specific Function Catalyzes the FAD-dependent oxidative deamination of various amines and D-amino acids to yield the corresponding alpha-keto acids, ammonia/amine, and hydrogen peroxide. Oxidizes sarcosine (N-methylglycine), N-ethylglycine and glycine., Kan ook het herbicide glyfosaat (n-fosfonomethylglycine) oxideren. Toont lagere activiteiten op d-alanine, d-valine, d-proline en D-methionine. Werkt niet op L-aminozuren en andere D-aminozuren. Is essentieel voor de biosynthese van thiamine aangezien de oxidatie van glycine gekatalyseerd door ThiO het glycine imine intermediair (dehydroglycine) genereert die nodig is voor de biosynthese van de thiazole ring van thiamine pyrofosfaat.,>

Resource Link UniProtKB ID O31616 UniProtKB Entry Name GLOX_BACSU GenBank Protein ID 2633520 GenBank Gene ID Z99110

General References

Drug Relations

Drug Relations

DrugBank ID Name Drug group Pharmacological action?, Actions Details
DB02713 Acetylamino-Acetic Acid experimental unknown Details
DB03147 Flavin adenine dinucleotide approved unknown Details